Prediabetes is a condition characterized by elevated blood glucose levels that are not high enough to be classified as type 2 diabetes. It is a critical stage where timely intervention can prevent or delay the progression to diabetes. Factors such as obesity, sedentary lifestyle, and genetic predisposition play a significant role in its development. Early detection through screening and lifestyle modifications like healthy eating, increased physical activity and weight management are essential in managing prediabetes.
A liquid biopsy is a minimally invasive medical test that analyzes a blood sample (or other body fluids, like urine or cerebrospinal fluid) to detect cancer or other diseases. Unlike traditional biopsies, which involve removing tissue samples from tumors, liquid biopsies offer a way to gather information about diseases from circulating molecules or cells shed into the bloodstream.
Fat-soluble vitamins, including A, D, E, and K, dissolve in fat and are stored in the body. They play vital roles in immune function, bone health, and protection against cell damage. Unlike water-soluble vitamins, they can be stored in the body for longer periods. Balancing these vitamins in the diet is crucial for overall health. fat-soluble vitamins are indispensable for our health, aiding in immune support, bone strength, and cell protection. These vitamins, including A, D, E, and K, are stored in the body's fat tissues and require a balanced diet for optimal well-being.
Coronavirus disease 2019 (COVID-19) has rapidly spread across the globe since its outbreak in Wuhan, China, in 2019. Clinical evidence suggests higher oxidative stress in COVID-19 patients, and this worsening redox status which may contribute to disease progression. The present study aimed to investigate the oxidative Deoxyribonucleic acid damage in patients with mild and severe COVID-19 infection and to evaluate its relationship tothe disease progression and severity.A case-control study was conducted from September 2021 to January 2022 in Duhok city, Kurdistan Region-Iraq. 180individuals have participated. Among 88 COVID-19 cases, 92 healthy volunteers as the control group, withages ranging (18-45) years. Patients were divided into two groups according to the severity of infection (mild cases, severe cases). Serum level of 8-OHdG and malondialdehyde (MDA) were assessed as oxidative stress biomarkers. Serum levels of 8-OHdG were considerably higher in patients with COVID-19 infection in comparison to the control group, (p<0.01). The further statistical analysis has revealed a significantly higher 8-OHdG in blood in female cases with severe COVID-19 infection compared cases with a mild infection, (p<0.01). Serum MDA levels in severe cases werehigher,statistically significant when compared with the control group (p=0.007). Severe cases had higher level of MDAthanin mild case, in male cases (p<0.05) in female cases (p<0.0001). The current data suggest that patients who were infected severely with COVID-19 are under huge oxidative stress attack. Analysis of data shows that severe cases of COVID-19 infection had significantly greater level of serum 8-OHdG than in healthy control subjects